HORDB

ID: hor005979
Uniprot ID: P43443
Protein name: Neuromedin-B
Gene name: nmb
Organism: Xenopus laevis (African clawed frog)
Family: Bombesin/neuromedin-B/ranatensin family
Source: Animal
Expression: Brain, intestine, and ovaries and early embryos (stages 2 and 10).
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: GNQWAIGHFM
Length: 10(45-54)
Propeptide: MSAVPLTRMLPLRFLTHLLLLSFIPLYFCMEFSEDARNIEKIRRGNQWAIGHFMGKKSLQDTYNPSEQDMDSEDFRPRIIEMIRGTFRQEPIRALSPRKQDEIQWMLKKIMDDYIKTTQK
Signal peptide: MSAVPLTRMLPLRFLTHLLLLSFIPLYFC
Modification: T10 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005979_AF2.pdb

hor005979_ESM.pdb

Mass:	132104	Formula:	C53H73N15O13S
Absent amino acids:	CDEKLPRSTVY	Common amino acids:	G
pI:	7.55	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	4
Hydrophobicity:	-9	Boman Index:	-57
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	49
Instability Index:	-3243	Extinction Coefficient cystines:	5500
Absorbance 280nm:	611.11

PubMed ID: 1409705
Title: Isolation and sequence of a cDNA encoding the precursor of a bombesinlike peptide from brain and early embryos of Xenopus laevis.